Title	Stereochemistry of Inorganic Compounds
Code	ÚCHV/SAZ1/03	Teacher	Černák Juraj
ECTS credits	4	Hrs/week	-/3
Assessment	Assessment	Semester	1, 3
T/L method	Practical
Content	Symmetry, elements of symmetry, point groups, symmetrical properties of orbitals and bonds. Principles of stereochemistry, VSEPR, configuration of molecules, polyhedra, regular and semiregular polyhedra. Valence shells with 4 to 12 electron pairs, geometry of molecules and periodic system.
Recommended reading	Kepert, D. L.: Inorganic Stereochemistry. Spribger-Verlag, Berlin, 1982 Kettle, S. F. A.: Symmetry and Structure. John Wiley & Sons, New York, 1985

Title	Seminar on Advanced Inorganic Chemistry
Code	ÚCHV/NPC1a/00	Teacher
ECTS credits	1	Hrs/week	-/1
Assessment	Assessment	Semester	1
T/L method	Practical
Objective	To acquaint students with the current state of research in inorganic chemistry.
Content	Selected topics in inorganic and coordination chemistry. Study of the scientific literature and publications. Elaboration of the chemical information.
Recommended reading	Actual scientific papers and literature concerning the actual research topics in inorganic chemistry Shriver D.F. Shriver, Atkins P.W.: Inorganic Chemistry. Oxford University Press, Oxford 1999

Title	Seminar on Advanced Inorganic Chemistry
Code	ÚCHV/NPC2/02	Teacher
ECTS credits	1	Hrs/week	-/1
Assessment	Assessment	Semester	2
T/L method	Practical
Objective	To acquaint students with the current state of research in inorganic chemistry.
Content	Selected topics in inorganic and coordination chemistry. Study of the scientific literature and publications. Elaboration of the chemical information.
Recommended reading	Actual scientific papers and literature concerning the actual research topics in inorganic chemistry Shriver D.F. Shriver, Atkins P.W.: Inorganic Chemistry. Oxford University Press, Oxford 1999

Title	Nuclear Chemistry
Code	ÚCHV/JCH1/04	Teacher	Turoňová Andrea, Markušová Kvetoslava
ECTS credits	4	Hrs/week	2/1
Assessment	Examination	Semester	2
T/L method	Lecture, Practical
Objective	To provide students with knowledge of the basics of radioactivity and nuclear reactions, of preparation of the radionuclides and their use in technical practice, and of the biological effects of nuclear radiation.
Content	Fundamentals of nuclear chemistry. Elementary particles. Nuclear core. Nuclides and isotopes. Radioactivity and radioactive disintegration kinetics. Radioactive disintegration. Decay law. Half life period. Units of radioactivity. Nuclear reactions. Sources of nuclear radiation. Detection and registration of radiation. Nuclear chemical technology. Radioactive analytical methods. Isotopic dilution method, activation analysis. Biological effects of the nuclear radiation. Nuclear medicine. Nuclear power station.
Recommended reading	G.R. Choppin, J. Rydberg: Nuclear Chemistry, Theory and Applications Pergamon Press,1980 G.R. Choppin, J.O. Liljenzin, J. Rydberg: Radiochemistry and nuclear chemistry, 3rd edition, Woburn, USA, Butterworth-Heinemann, 2002 W.D. Ehmann, D.E. Vance: Radiochemistry and nuclear methods of analysis, Wiley, New York, 1991 A. Vértes, I. Kiss: Nuclear chemistry, Elsevier,1987

Title	Inorganic Polymers, Clusters and Organometallics
Code	ÚCHV/AKO/03	Teacher	Černák Juraj, Chomič Jozef
ECTS credits	6	Hrs/week	3/1
Assessment	Examination	Semester
T/L method	Lecture, Practical
Content	Definition and classification of inorganic polymers. Linear polymers S, Se, Te, (SN)x. Chalkogenic glasses, BN, borate glasses. Quartz and silicate glasses. Crystalline silicates and aluminosilicates. Boranes and heteroboranes, polyoxovanadium compounds. Hetero- and isopolyanions. Polymeric cyanocomplexes. Cluster compounds,   metal-metal bonding in clusters, intersticial atoms. Organometallic compounds, bondings M-C; types of ligands, their preparation and their propereties.
Prerequisite courses	ÚCHV/ACH2/03 or
Recommended reading	Ray, N.H.: Inorganic Polymers, Academic Press, New York, 1978. Haiduc I., Zuckerman J.J.: Basic Organometallic Chemistry, W. de Gruyter, Berlin, N.Y. 1985.

Title	Thermal Analysis
Code	ÚCHV/TA1/03	Teacher	Györyová Katarína
ECTS credits	5	Hrs/week	2/1
Assessment	Examination	Semester
T/L method	Lecture, Practical
Objective	To provide students with knowledge of experimental thermoanalytical techniques, the use of thermoanalytic methods for characterisation of inorganic and organic compounds and reaction kinetics.
Content	Introduction: Experimental thermoanalytical techniques (thermogravi-metric analysis, differential thermal analysis, thermomagnetic techniques, thermodilatometric analysis, high temperature reflectance spectroscopy). The use of thermoanalytic methods for characterisation of inorganic and organic compounds, materials and pharmaceutical substances. Reaction kinetics.
Recommended reading	Wendlandt W. W.: Thermal Methods of Analysis, 2nd ed., New York, 1985

Title	Adsorption and Porosity of Solids
Code	ÚCHV/ADP/03	Teacher	Zeleňák Vladimír
ECTS credits	5	Hrs/week	2/1
Assessment	Assessment	Semester	2
T/L method	Lecture, Practical
Objective	To familiarise students with various types of porous solids and basic methods for their investigation.
Content	Terminology associated with powders, porous solids and adsorption. Methodology of adsorption at the gas-solid interface and at the liquid-solid interface. Assessment of surface area and porosity. Inorganic materials (active carbon, metal oxides, zeolites, clay minerals, new advanced materials) and the phenomenon of adsorption. Application in industry and everyday life.
Recommended reading	F. Rouquerol, J. Rouquerol, K. Sing: Adsorption by powders and porous solids, Academic press, London, UK, 1999 S. J. Gregg, K.S.W. Sing: Adsorption, surface area and porosity, Academic Press, London,, UK, 1982

Title	Computing Methods in X-Ray Structure Analysis
Code	ÚCHV/VMS1/03	Teacher
ECTS credits	2	Hrs/week	-/2
Assessment	Assessment	Semester	2
T/L method	Practical
Objective	To provide students with basic knowledge on the use of crystallographic and crystal structure visualisation programs on personal computers
Content	Cambridge Crystal Structure Database: the use of the data from CCSD and published papers. Calculation of geometric parameters including hydrogen bonds (program PARST). Graphic visualisation of crystal structures (program DIAMOND. Use of the Internet for transfer of crystallographic data; interesting crystallographic web sites. The programs for crystal structure analysis: SHELX.
Prerequisite courses	ÚCHV/STA1/03 orÚCHV/USA/03 orÚCHV/MIN1/00

Title	Mechanisms of Inorganic Reactions
Code	ÚCHV/MAR1/04	Teacher	Reháková Mária
ECTS credits	3	Hrs/week	1/1
Assessment	Assessment	Semester	2
T/L method	Lecture, Practical
Content	Classification of chemical reactions according to mechanisms found in specific aspects of the reactions of coordination compounds. Kinetic and thermodynamic properties of chemical reactions. SN1, SN2, SE1 and SE2 types of reaction mechanisms. Mechanisms in coordination and inclusion compounds. Practical application of knowledge of reaction mechanisms.
Recommended reading	Shriver D.F. Shriver, Atkins P.W.: Inorganic Chemistry. Oxford University Press, Oxford 1999

Title	Chemical Toxicology
Code	ÚCHV/TOX1/03	Teacher	Györyová Katarína
ECTS credits	5	Hrs/week	2/1
Assessment	Examination	Semester	3
T/L method	Lecture, Practical
Objective	To provide students with knowledge of toxic substances and their toxic effect and of  interactions between chemicals and biological systems.
Content	Historical aspects, types of toxic substances, dose-response relationship. Disposition of toxic compounds (absorption, distribution, excretion, metabolism of toxic compounds, factors affecting toxic responses). Types of exposure and response. Drugs as toxic substances. Industrial toxicology. Food additives and contaminants. Pesticides. Environmental pollutants. Natural products. Risk and safety practices with chemical substances, designation of substances in accordance with the norms of the European Union and the laws of the Slovak Republic.
Recommended reading	J. A. Timbrell: Introduction to Toxicology, Taylor and Francis, London 1989 V. E. Forbes, T. L. Forbes: Toxicology in Theory and Practice, Chapmane Hall, London 1994 H. M. Stahr: Analytical Methods in Toxicology, John Wiley & Sons, New York 1991

Title	Solid State Chemistry
Code	ÚCHV/CTF1/00	Teacher	Černák Juraj, Tkáčová Klára
ECTS credits	5	Hrs/week	2/1
Assessment	Examination	Semester	3
T/L method	Lecture, Practical
Objective	To provide students with basic knowledge on the fundamentals and significance of solid state chemistry and of reaction in the solid state.
Content	Historical development of solid state chemistry and its significance for technological progress. General fundamentals and important properties of solids: ideal and real crystals, deformation of crystals, diffusion in solids. Non-catalysed reactions involving solids: thermal decomposition, surface oxidation, reaction between solids, chemical dissolution. The influence of non-equilibrium defects on the reactivity of solids. Generation of defects by various methods of treatment: rapid quenching, doping, irradiation, mechanical activation and low temperature decomposition.
Alternate courses	ÚCHV/CTF1/99
Recommended reading	West A.R.: Basic Solid State Chemistry, J. Wiley, Chichester, 1999. Tkáčová, K.: Mechanical Activation of minerals. Elsevier, Amsterdam, 1989

Elective courses

Title	History of Natural Science
Code	ÚCHV/DPV1/03	Teacher	Ganajová Mária
ECTS credits	5	Hrs/week	2/1
Assessment	Examination	Semester	1, 3
T/L method	Lecture, Practical
Content	Basic patterns of the emergence of chemistry in relation to the rest of the natural sciences. Stages in the emergence of chemistry. Matter and the meaning of alchemy. Chemistry of air.  Discoveries of basic quantitative laws. Ideas of evolution.  The structure of substances; models of atoms. Classification of elements:  Periodic Table. The current state of chemistry.

Title	Chemical management
Code	ÚCHV/CMG/03	Teacher	Koščík Dušan
ECTS credits	5	Hrs/week	3/-
Assessment	Examination	Semester	1
T/L method	Lecture
Objective	To expose students to the basic principles of production management, marketing, and strategy building in the chemical and pharmaceutical industries through lectures by top managers from Slovak chemical companies.
Content	Basic processes connected to manufacturing and management of chemical production in Slovakia.
Recommended reading	Internal sources

Title	Chemical Excursion
Code	ÚCHV/CHE2/03	Teacher	Vargová Zuzana
ECTS credits	4	Hrs/week	-/1t
Assessment	Assessment	Semester	2, 4
T/L method	Practical
Content	Visit to chemical factories in East Slovakia (Kerko, a.s. Košice - manufactury Michalovce, U.S. Steel s.r.o. - Košice, Vsl. stavebné hmoty, a.s. - Turňa nad Bodvou, Chemko, a.s. - Strážske, Kovohuty, a.s. Krompachy).

Study programme   Organic Chemistry

(Full-time master)

Code   Title   ECTS   Credit   Hours/week   Assessment   Recommended Year/Semester

Compulsory courses

ÚCHV/BOC/03	Bio-organic Chemistry	5	3/-	Examination	1/1
ÚCHV/PRL/04	Chemistry of Natural Compounds	4	2/1	Examination	1/1,2,3
ÚCHV/OS/03	Organic Synthesis	5	2/1	Examination	1/1
ÚCHV/DPCO1a/00	Diploma Work	2	-/-	Recognition	1/1
ÚCHV/AS1/03	Asymmetric Synthesis	5	2/1	Examination	1/2
ÚCHV/NMR1/00	1D & 2D NMR Spectroscopy	6	2/3	Examination	1/2
ÚCHV/MSM1/00	Modern Synthetic Methods	6	3/1	Examination	1/2
ÚCHV/DPCO1b/00	Diploma Work	6	-/-	Recognition	1/2
ÚCHV/DPCO1c/03	Diploma Work	2	-/-	Recognition	2/3
ÚCHV/SEM1a/00	Seminar on Diploma Work	2	-/2	Assessment	2/3
ÚCHV/DPCO1d/03	Diploma Work	30	-/-	Recognition	2/4
ÚCHV/SEM1b/00	Seminar on Diploma Work	2	-/2	Assessment	2/4

Compulsory elective courses

ÚCHV/SMCH/03	Supramolecular Chemistry	4	2/1	Examination	1/1, 2/3
ÚCHV/TOXOL/03	Toxicology of Organic Compounds	4	3/-	Examination	1/1
ÚCHV/MM1/00	Molecular Modelling	4	1/3	Assessment	1/1
ÚCHV/NCH/03	Neurochemistry	5	2/1	Examination	1/2
ÚCHV/ZCI/04	Basic Cheminformatics Tools	2	2/1	Examination	1/2
ÚCHV/HZ1/00	Heterocyclic Compounds	4	2/1	Examination	1/1, 2/3
ÚCHV/CHOZ/03	Organometallic Compounds	4	2/1	Examination	2/3
ÚCHV/KOC1/01	Quantum Chemistry	5	3/1	Examination	2/3
ÚCHV/KC/03	Cosmetic Chemistry	4	2/1	Examination	1/1, 2/3

Elective courses

ÚCHV/FMCH/04	Medicinal Chemistry	6	3/1	Examination	1/1,2/3
ÚCHV/KOR1/00	Organic Reaction Kinetics	4	2/1	Examination	1/1
ÚCHV/NSM/04	New Spectroscopic Methods	2	2/1	Examination	1/2
ÚCHV/SVK1/00	Student Scientific Conference	4	-/-	Assessment	1/2, 2/4
ÚCHV/CMG/03	Chemical Management	5	3/-	Examination	2/3
ÚCHV/PCH1/00	Food Chemistry	4	2/1	Examination	2/3
ÚCHV/EMDP/03	Experimental Methods for Master’s Thesis	6	-/6	Assessment	2/3

Course units

Compulsory courses

Title	Bioorganic Chemistry
Code	ÚCHV/BOC/03	Teacher	Gonda Jozef
ECTS credits	5	Hrs/week	3/-
Assessment	Examination	Semester	1
T/L method	Lecture
Objective	To teach students the fundamental principles for the construction of bioorganic molecular models of biochemical processes using the tools of organic chemistry.
Content	Introduction: Basic considerations; proximity effects in biochemistry, Molecular adaptation. Molecular recognition at the supramolecular level. Bio-organic chemistry of amino acids and polypeptides: chemistry of the living cells, Analoguey between organic reactions and biochemical tranformations, Chemistry of the peptide bond: nonribosomal peptide formation, asymmetric synthesis of amino acids, asymmetric synthesis with chiral organometalic catalysts, Transition state analogues. Antibodies as enzymes. Chemical mutations. Molecular recognition and drug design. Bio-organic chemistry of the phosphate groups and polynucleotides:d energy storage, DNA intercalates, RNA molecules as catalysts. Enzyme chemistry: introduction to catalysis and enzymes, Multifuntional catalysis and simple models. Alpha-chymotrypsin. Other hydrolytic enzymes. Strereoelectronic control in hydrolytic reactions. Immobilised enzymes. Enzymes in synthetic organic chemistry. Enzyme-Analogue-Built polymers. Design of molecular clefts. Enzyme Models: host-guest complexation chemistry, New developments in crown ether chemistry, Membrane chemistry and micelles. Polymers. Cyclodextrins. Enzyme design using steroid template. Remote functionalisation reactions. Polyene biomimetic cyclisations. Metal Ions: in proteins and biological molecules. Carbopeptidase A. Hydrolysis of amino acid esters and peptides. Iron and oxygen transport. Cooper ion. Cobalt and vitamin B12 action. Oxidoreduction. Pyridoxal phosphate. Biotin.
Recommended reading	Voet J. : Biochemistry, Springer Verlag, 1992 Dugas H.: Bioorganic Chemistry, Springer Verlag, 1999

Title	Chemistry of Natural Compounds
Code	ÚCHV/PRL/04	Teacher	Martinková Miroslava
ECTS credits	4	Hrs/week	2/1
Assessment	Examination	Semester	1, 3
T/L method	Lecture, Practical
Objective	To provide students with general information about atractive natural products from various living organisms.
Content	General introduction, nomenclature, occurrence, isolation, detection, structure elucidation, biosynthesis, synthesis,  biological activity and comercial aplications of natural compounds, such as: saccharides, lipids, amino acids, alkaloids, terpenoids, steroids, vitamins.
Recommended reading	S. V. Bhat, B. A. Nagasampagi, M. Sivakumar: Chemistry of natural compounds, Springer Narosa 2005

Title	Organic Synthesis
Code	ÚCHV/OS/03	Teacher	Kutschy Peter
ECTS credits	5	Hrs/week	2/1
Assessment	Examination	Semester	1
T/L method	Lecture, Practical
Objective	To teach students the most important methods for the synthesis of organic compounds, their combination and application in the synthesis of complex molecules.
Content	Formation of carbon-carbon single and double bonds. Synthesis of main groups of organic compounds (halogen derivatives, oxygen, nitrogen and sulphur containing compounds). Transformation and protection of functional groups. Retrosynthetic analysis.
Recommended reading	Carruthers W., Coldham I.: Modern Methods of Organic Synthesis, Fourth Edition, Cambridge University Press, 2005 Comprehensive Organic Synthesis Trost B. M., Fleming I., Eds., Vol. 1-9, Pergamon Press, Oxford, 1991

Title	Diploma Work
Code	ÚCHV/DPCO1a/00	Teacher
ECTS credits	2	Hrs/week	-/-
Assessment	Recognition	Semester	1
Objective	To allow a student, under the guidance of supervisor, to learn the problems to be solved within diploma work, elaborates the plan of his/her experiments and starts the experimental work.
Content	Study of the recommended literature; literature search in the problems of diploma work; preparation and starting of experiments.
Recommended reading	According to the approved setting of diploma work.

Title	1D & 2D NMR Spectroscopy
Code	ÚCHV/NMR1/00	Teacher	Imrich Ján
ECTS credits	6	Hrs/week	2/3
Assessment	Examination	Semester	2
T/L method	Lecture, Practical
Objective	To teach students how to analyse the structure and properties of organic, inorganic and biomolecular compounds by 1D and 2D proton and carbon NMR spectra, quantitative NMR analysis, and practical applications in various fields of science and technology.
Content	Theoretical principles of nuclear magnetic resonance (NMR), basic NMR pulse techniques and Fourier transformation, NMR spectrometers, description of NMR by vector models. Parameters of one- (1D) and two-dimensional (2D) NMR spectra, practical application of 1H and 13C NMR spectra and basic correlated 2D spectra for structure and stereo chemical arrangement, elucidation of reaction mechanisms, molecular dynamics, physico-chemical properties and quantitative analysis of chemical compounds.
Alternate courses	ÚCHV/NMR1/99
Recommended reading	Friebolin H.: Basic One- and Two-Dimensional NMR Spectrocopy, Verlag Chemie, Weintheim 1993 T.D.W. Claridge: High-Resolution NMR Techniques in Organic Chemistry, Elsevier, 1999 Atta-ur-Rahman, M. I. Choudhary: Solving Problems with NMR spectroscopy, Academic Press 1996   H.-O. Kalinowski, S. Berger, S. Braun: Carbon-13 NMR Spectroscopy. Wiley New York, 1922 A. E. Derome: Modern NMR Techniques for Chemistry Research. Pergamon Press Oxford, 1927 E. Pretsch, B. Buhlmann, C. Affolter: Structure Determination of Organic Compounds. Tables of Spectral Data. Springer Verlag Berlin, 2000 E. Breitmaier: Vom NMR-Spektrum zur Strukturformel organischer Verbindungen. B. G. Teubner Stuttgart 1992 E. Breitmaier, W. Voelter: Carbon-13 NMR Spectroscopy. VCH Weinheim, 1990

Title	Modern Synthetic Methods
Code	ÚCHV/MSM1/00	Teacher	Martinková Miroslava, Kutschy Peter, Gonda Jozef
ECTS credits	6	Hrs/week	3/1
Assessment	Examination	Semester	2
T/L method	Lecture, Practical
Objective	To teach students to understand modern methods in the synthesis of organic compounds.
Content	Concepts, methods, starting materials, and target molecules that play important roles in modern organic synthesis. The concept of synthons, retrosynthetic analysis of simple organic molecules, asymmetric synthesis, nucleophilic addition, oxidation, reduction, protection of functional groups.
Alternate courses	ÚCHV/MSM1/99
Recommended reading	Comprehensive organic synthesis. Trost B. M., Fleming I., Eds. Vol. 1-9. Pergamon Press, Oxford 1991 J. Fuhrhop, G. Penzlin: Organic synthesis, VCH Weinheim, 1994

Title	Diploma Work
Code	ÚCHV/DPCO1b/00	Teacher
ECTS credits	6	Hrs/week	-/-
Assessment	Recognition	Semester	2
Objective	To have students perform the experiments required for diploma work.
Content	Individual experimental work of student and study of required literature.
Prerequisite courses	ÚCHV/DPCO1a/00
Automatic rerequisite courses	ÚCHV/DPCO1a/00
Recommended reading	According to the approved setting of diploma work and literature search.

Title	Diploma Work
Code	ÚCHV/DPCO1c/03	Teacher
ECTS credits	2	Hrs/week	-/-
Assessment	Recognition	Semester	3
Objective	To have students perform the experiments required for diploma work and to process their results.
Content	Individual experimental work of student and continuous processing of the obtained results.
Prerequisite courses	ÚCHV/DPCO1b/00
Recommended reading	According to the approved setting of diploma work and student’s own literature search.

Title	Diploma Work
Code	ÚCHV/DPCO1d/03	Teacher
ECTS credits	30	Hrs/week	-/-
Assessment	Recognition	Semester	4
Objective	To have students finish their experiments, process their results, and learn how to write a thesis.
Content	Finishing the student’s experimental work, processing of the obtained results and writing the diploma work.
Prerequisite courses	ÚCHV/DPCO1c/03
Recommended reading	According to the approved setting of diploma work and student’s own literature search.

Compulsory elective courses

Title	Toxicology of Organic Compounds
Code	ÚCHV/TOXOL/03	Teacher	Martinková Miroslava
ECTS credits	4	Hrs/week	3/-
Assessment	Examination	Semester	3
T/L method	Lecture
Objective	To examine the interaction between chemicals and biological systems in order for students to quantitatively determine the potential for chemicals to produce harmful effects in living organisms.
Content	General principles of toxicology. Absorption, distribution and excretion of toxicants. Biotransformation of xenobiotics: phase-1 reactions (oxidation, reduction, hydrolysis), phase-2 reactions (conjugation reactions). Toxication versus detoxication. Toxic effects of organic solvents. Toxicology of chemical warfare agents. Neurotoxicology. Toxic effects of plants and animal poisons. Toxic effects of drugs (barbiturates, benzodiazepines, tricyclic antidepressants). Drug dependence.
Recommended reading	C. D. Klaassen: Casaret and Doull`s Toxicology: The basic science of poisons, McGraw-Hill Companies, Inc., 2001

Title	Molecular Modelling
Code	ÚCHV/MM1/00	Teacher	Török Marcel
ECTS credits	4	Hrs/week	1/3
Assessment	Assessment	Semester	3
T/L method	Lecture, Practical
Objective	To teach students the basic skills and theory necessary for the realisation of  computational experiments in chemistry using specialised software packages. Students will be able to perform theoretical studies of the structure and electronic properties of small and middle-sised molecules and study the thermodynamical and structural aspects of chemical reactions.
Content	Basic concepts. Reality vs. model: quantum mechanical models I, quantum mechanical models II, quantum mechanical models III, empirical force field models I, empirical force field models II, solvation models. Methods for exploring the energy surface: conformational analysis of molecules I, conformational analysis of molecules II. Exploring of the reaction pathways. Molecular dynamics and computer simulations. Overview of the software tools for molecular modelling., Presentation of the seminar project.
Recommended reading	LEACH, Andrew R.: Molecular Modelling: Principles and Applications JENSEN, Frank: An Introduction to Computational Chemistry  Manuals for MOPAC, HYPERCHEM, GAMESS, GAUSSIAN