|
Title
|
Bioinorganic Chemistry I
|
||
|
Code
|
ÚCHV/BAC1/04
|
Teacher
|
Reháková Mária
|
|
ECTS credits
|
5
|
Hrs/week
|
2/1
|
|
Assessment
|
Examination
|
Semester
|
1
|
|
T/L method
|
Lecture, Practical
|
||
|
Content
|
Metalic and
non-metalic elements and their roles in biological systems (biometals, bulk
biological elements, essential trace elements). Biocoordination compounds,
bioligands. Biocatalyzers. Oxygen carriers and oxygen transport proteins.
Photochemical process. Catalysis and regulation of bioenergetic processes by
the alkaline earth metal ions. Calcium biominerals and biomineralisation.
Toxic metals. Application of knowledge of bioinorganic chemistry in pharmacy,
chemotherapy (e.g. platinum complexes in cancer therapy) radiodiagnostics,
mineral biotechnology, and in other branches of life.
|
||
|
Recommended reading
|
Kaim W., Schwederski B.: Bioinorganic Chemistry:
Inorganic Elements in the Chemistry of
Life. Wiley, Chichester 1998.
Wilkins P. C., Wilkins R. G.: Inorganic Chemistry in
Biology. OCP, Oxford 1997
Hay R. W.: Bio-inorganic Chemistry. John Wiley and
Sons, New York 1989
|
||
|
Title
|
Structure Analysis
|
||
|
Code
|
ÚCHV/STA1/03
|
Teacher
|
Černák Juraj
|
|
ECTS credits
|
6
|
Hrs/week
|
2/2
|
|
Assessment
|
Examination
|
Semester
|
1
|
|
T/L method
|
Lecture, Practical
|
||
|
Objective
|
To teach
students about symmetry at the micro- and macrostructural level, about diffraction methods used for crystal
structure determination and how to use the results of the crystal structure
analysis in their own work.
|
||
|
Content
|
Historical
introduction: importance of diffraction methods. Origin and properties of
x-rays. Elements of symmetry; space groups. Crystallographic systems; Bravais
unit cells. Miller indices. Theory of diffraction; Laue and Bragg equations.
Reciprocal space; Ewald construction. Single crystal diffraction methods;
automatic diffractometers. Powder diffraction: Debye-Scherrer and
diffractometric methods, their theory and use. Atomic factor, structure
factor, electronic density and their relationship. The phase problem:
overview of the methods for solving the phase problems. Refinement of the
structure; geometric parameters. Crystallisation processes; methods of
preparation of single crystals. Density. Basic inorganic structure types.
|
||
|
Recommended reading
|
Clegg W.: Crystal Structure Determination, Oxford
University Press, 1998
Luger, P.: Modern X-ray Analysis on Single Crystals.
Walter de Gruyter, Berlin, 1980
|
||
|
Title
|
Stereochemistry of Inorganic Compounds
|
||
|
Code
|
ÚCHV/SAZ1/03
|
Teacher
|
Černák Juraj
|
|
ECTS credits
|
4
|
Hrs/week
|
-/3
|
|
Assessment
|
Assessment
|
Semester
|
1
|
|
T/L method
|
Practical
|
||
|
Content
|
Symmetry,
elements of symmetry, point groups, symmetrical properties of orbitals and
bonds. Principles of stereochemistry, VSEPR, configuration of molecules,
polyhedra, regular and semiregular polyhedra. Valence shells with 4 to 12
electron pairs, geometry of molecules and periodic system.
|
||
|
Recommended reading
|
Kepert, D. L.: Inorganic Stereochemistry.
Springer-Verlag, Berlin, 1982.
Kettle, S. F. A.: Symmetry and Structure. John Wiley
& Sons, New York, 1985.
|
||
|
Title
|
Solid State Chemistry
|
||
|
Code
|
ÚCHV/CTF1/00
|
Teacher
|
Černák Juraj, Tkáčová Klára
|
|
ECTS credits
|
5
|
Hrs/week
|
2/1
|
|
Assessment
|
Examination
|
Semester
|
1
|
|
T/L method
|
Lecture, Practical
|
||
|
Objective
|
To provide
students with basic knowledge on the fundamentals and significance of solid
state chemistry and of reaction in the solid state.
|
||
|
Content
|
Historical
development of solid state chemistry and its significance for technological
progress. General fundamentals and important properties of solids: ideal and
real crystals, deformation of crystals, diffusion in solids. Non-catalysed
reactions involving solids: thermal decomposition, surface oxidation,
reaction between solids, chemical dissolution. The influence of
non-equilibrium defects on the reactivity of solids. Generation of defects by
various methods of treatment: rapid quenching, doping, irradiation,
mechanical activation and low temperature decomposition.
|
||
|
Alternate courses
|
ÚCHV/CTF1/99
|
||
|
Recommended reading
|
West A.R.: Basic Solid State Chemistry, J. Wiley,
Chichester, 1999.
Tkáčová, K.: Mechanical Activation of Minerals.
Elsevier, Amsterdam, 1989.
|
||
|
Title
|
Basic Toxicology
|
||
|
Code
|
ÚCHV/ZTOX/04
|
Teacher
|
Györyová Katarína
|
|
ECTS credits
|
5
|
Hrs/week
|
2/1
|
|
Assessment
|
Examination
|
Semester
|
1
|
|
T/L method
|
Lecture, Practical
|
||
|
Objective
|
To provide
students with knowledge of types of toxic substances and their metabolism and
of the safe handling of toxic
substances.
|
||
|
Content
|
Historical
aspects. Types of toxic substances, types of exposure, dose-response
relationship. Disposition of toxic compounds (absorption, distribution,
excretion of toxic compounds). Metabolism of toxic compounds. Drugs as toxic
substances, food additives and contaminants, environmental pollutants.
Statement of chemistry laboratory policy. Safe handling of toxic substances.
|
||
|
Recommended reading
|
G. F.Fuhrman: Allgemeine Toxikologie fuer Chemiker,
Teubner Verlag, Stutgart 1984
V. E. Forbes, T. L. Forbe: Ecotoxicology in Theory
and Practice, Chapman&Hall, London 1994.
J. A. Timbrell: Introduction to Toxicology,
Taylor&Francis, London 1994
|
||
|
Title
|
Seminar on Advanced Inorganic Chemistry
|
||
|
Code
|
ÚCHV/NPC2/02
|
Teacher
|
|
|
ECTS credits
|
1
|
Hrs/week
|
-/1
|
|
Assessment
|
Assessment
|
Semester
|
2
|
|
T/L method
|
Practical
|
||
|
Objective
|
To acquaint
students with the current state of research in inorganic chemistry.
|
||
|
Content
|
Selected
topics in inorganic and coordination chemistry. Study of the scientific
literature and publications. Elaboration of the chemical information.
|
||
|
Recommended reading
|
Actual scientific papers and literature concerning
the actual research topics in inorganic chemistry.
Shriver D. F. Shriver, Atkins P. W.: Inorganic
Chemistry. Oxford University Press, Oxford 1999
|
||
|
Title
|
Bioinorganic Chemistry II
|
||
|
Code
|
ÚCHV/BAC2/05
|
Teacher
|
Györyová Katarína
|
|
ECTS credits
|
5
|
Hrs/week
|
2/1
|
|
Assessment
|
Examination
|
Semester
|
2
|
|
T/L method
|
Lecture, Practical
|
||
|
Objective
|
To provide
the students with knowledge of biocoordination compounds and their
physicochemical properties, e.g., the biological efficiency of some
coordination compounds with transition elements (Zn, Fe, Co, Mn, Cu).
|
||
|
Content
|
Biocoordination
compounds and their physicochemical properties. Metal centers in biosystems.
Biological efficiency of some coordination compounds with transition elements
(Zn, Fe, Co, Mn, Cu) and their utilisation in human and veterinary medicine.
Toxicity of biometals.
|
||
|
Prerequisite courses
|
ÚCHV/BAC1/04
|
||
|
Recommended reading
|
Kaim, W., Schwederski, B.: Bioinorganic Chemistry:
Inorganic Elements in the Chemistry of Life, John Wiley and Sons, Chichester
1994
|
||
|
Title
|
Methods of Chemical Research
|
||
|
Code
|
ÚCHV/MCV1/03
|
Teacher
|
Kladeková Daniela, Markušová Kvetoslava
|
|
ECTS credits
|
4
|
Hrs/week
|
2/1
|
|
Assessment
|
Examination
|
Semester
|
2
|
|
T/L method
|
Lecture, Practical
|
||
|
Objective
|
To
familiarise students with physicochemical parameters as a means of
measurement, evaluation, and interpretation in the study of a process.
|
||
|
Content
|
Overview of
basic principles of the determination of physicochemical quantities
(dissociation constant, activity coefficient, solubility product, stability
constant of complex, diffusion coefficient). Calorimetry and its utilisation.
Experimental methods in kinetics. The Butler-Volmer equation. Survey of
selected key topics in colloid chemistry. Adsorption-BET equation. A
discussion of topics selected from active research fields.
|
||
|
Recommended reading
|
Moore,W. J. : Physical Chemistry. Longman Group
Limited, London, 1972
Willard, H. H. et al.: Instrumental Methods of
Analysis. Wadsworth, Belmont, 1988
Koryta, J., Dvořák, J., Kavan, L.: Principles of
Electrochemistry. John Wiley & Sons, New York, 1993
|
||
|
Title
|
Neurochemistry
|
||
|
Code
|
ÚCHV/NCH/03
|
Teacher
|
Martinková Miroslava
|
|
ECTS credits
|
5
|
Hrs/week
|
2/1
|
|
Assessment
|
Examination
|
Semester
|
2
|
|
T/L method
|
Lecture, Practical
|
||
|
Objective
|
To teach
students the fundamental principles of chemical transmission between nerve
cells; to have students understand the necessary link between neuroanatomy
and neurochemistry.
|
||
|
Content
|
Neurocellular
anatomy - characteristics of the neuron. Cell membrane structures:
phospholipid bilayer, membrane proteins, brain lipids, brain lipids
biosynthesis. Membrane transport and ion channels. Synaptic transmission and
cellular signaling. Neurotransmitters: acetylcholine, catecholamines, serotonin,
amino acids (glutamate, aspartate, GABA, glycine). Neuropeptides:
neuropeptide functions and regulation. G-proteins; the second-messenger
hypothesis (cAMP, IP3, DAG, Ca2+). Neurotransmitters and disorders of the
basal ganglia. Endocrine effects on the brain and their relationship to
behaviour.
|
||
|
Recommended reading
|
G. J. Siegel, B. W. Agranoff, R. W. Albers, S. K.
Fisher, M. D. Uhler: Basic Neurochemistry, Lippincott Williams and Wilkins,
Philadelphia 1999
|
||
|
Title
|
Molecular Biology
|
||
|
Code
|
ÚBEV/MB1/01
|
Teacher
|
Mišúrová Eva
|
|
ECTS credits
|
4
|
Hrs/week
|
3/-
|
|
Assessment
|
Examination
|
Semester
|
2
|
|
T/L method
|
Lecture
|
||
|
Objective
|
To provide
the students with knowledge of molecular basis of inheritance and control of
gene expression and development.
|
||
|
Content
|
Structure
and properties of information macromolecules. Molecular mechanisms of DNA
replication and repair, transcription and translation. Prokaryotic and
eukaryotic genome. Control of gene expression in prokaryotes and eukaryotes.
Control of cell cycle.
|
||
|
Recommended reading
|
Lodish, H., Baltimore, D., Berk, A. et al.: Molecular
Cell Biology. Sci. Amer. Books Inc., W.H. Freeman and Company, New York,
1995.
Myers, R. A.: Molecular Biology and Biotechnology.
VCH Publishers Inc., New York, 1995
|
||
|
Title
|
Thermal Analysis
|
||
|
Code
|
ÚCHV/TA1/03
|
Teacher
|
Györyová Katarína
|
|
ECTS credits
|
5
|
Hrs/week
|
2/1
|
|
Assessment
|
Examination
|
Semester
|
2
|
|
T/L method
|
Lecture, Practical
|
||
|
Objective
|
To provide
students with knowledge of experimental thermoanalytical techniques, the use
of thermoanalytic methods for characterisation of inorganic and organic
compounds and reaction kinetics.
|
||
|
Content
|
Introduction:
Experimental thermoanalytical techniques (thermogravi-metric analysis,
differential thermal analysis, thermomagnetic techniques, thermodilatometric
analysis, high temperature reflectance spectroscopy). The use of
thermoanalytic methods for characterisation of inorganic and organic
compounds, materials and pharmaceutical substances. Reaction kinetics.
|
||
|
Recommended reading
|
Heide K.: Dynamische thermische Analysenmethoden, VEB
Deutsch Verlag Wissenschaften, Leipzig, 1979
|
||
|
Title
|
Bioinorganic Chemistry III
|
||
|
Code
|
ÚCHV/BAC3/04
|
Teacher
|
Zeleňák Vladimír
|
|
ECTS credits
|
5
|
Hrs/week
|
2/1
|
|
Assessment
|
Examination
|
Semester
|
2
|
|
T/L method
|
Lecture, Practical
|
||
|
Objective
|
To acquant
students with the current state of selected topics of the research in
bioinorganic chemistry.
|
||
|
Content
|
Singlet and
triplet dioxygen and organisms. Oxygen atom transfer reactions. Dioxygen
radical generating systems. Inorganic compounds as the analogues of the
active sites of the metalloproteins. Construction of small molecule enzyme
mimics as drugs (SOD mimics). Metals in medical applications (the use of
chelating agents, metal based chemotherapeutic drugs, metallodrugs as
diagnostic agents, metals as biomaterials). Physical methods.
|
||
|
Prerequisite courses
|
ÚCHV/BAC1/04
|
||
|
Recommended reading
|
W. Kaim, B. Schwederski: Bioinorganic Chemistry:
Inorganic Elements in the Chemistry of Life, Wiley, Chichester, England, 1994
J. A Helsen, H. J. Breme: Metals as Biomaterials,
Wiley, Chichester, England, 1998
P. C. Wilkins, R. G. Wilkins: Inorganic Chemistry in
Biology. Oxford University Press, Oxford 1997.
R.W. Hay: Bio-inorganic chemistry. Ellis Horwood
Ltd., Chichester, England, 1987
|
||
|
Title
|
Special Toxicology
|
||
|
Code
|
ÚCHV/STOX/04
|
Teacher
|
Györyová Katarína
|
|
ECTS credits
|
5
|
Hrs/week
|
2/1
|
|
Assessment
|
Examination
|
Semester
|
3
|
|
T/L method
|
Lecture, Practical
|
||
|
Objective
|
To provide
students with knowledge of the toxicology of organic and inorganic compounds,
drugs, food additives, e.g., safety of substances, designation of substances
in accordance with norms of the European Union and the laws of the Slovak
Republic.
|
||
|
Content
|
Historical
aspects, types of toxic substances, dosage (LD50, ED50, TD50, tolerance),
absorption and distribution of toxic compounds. Metabolism of toxic compounds
(oxidation reactions, reduction, glucuronidation, glutathione conjugation,
acetylation); excretion of toxic compounds; toxicology of metals (alkali,
alkali earth and transition metals), radioactive substances, drugs, food
additives, industrial chemicals, household poisons, environmental pollutants
and organic compounds, animal toxins, fungal and microbial toxins. Risk and safety practices with chemical
substances, designation of substances in accordance with the norms of the
European Union and the laws of the Slovak Republic.
|
||
|
Recommended reading
|
J. A. Timbrell: Introduction to Toxicology, Taylor
and Francis, London 1989
H. Kenneth Dillon, Mat H. Ho: Biological Monitoring
of Exposure to
Chemicals: Metals, John Wiley & Sons, New York
1991
V. E. Forbes, T. L. Forbes: Toxicology in Theory and
Practice, Chapmane Hall, London 1994
H. M. Stahr: Analytical Methods in Toxicology, John
Wiley & Sons, New York 1991
|
||
|
Title
|
Electrode Processes and Technology
|
||
|
Code
|
ÚCHV/ELD1/03
|
Teacher
|
Turoňová Andrea,
|
|
ECTS credits
|
4
|
Hrs/week
|
2/1
|
|
Assessment
|
Examination
|
Semester
|
1
|
|
T/L method
|
Lecture, Practical
|
||
|
Objective
|
To teach
students the various electrochemical processes and their applications in practical
technology.
|
||
|
Content
|
Theory of
the electrode processes. Electrolyser construction. Electrolysis of H2O.
Electrolysis of NaCl. Electrolytical deposition and refining of metal from
aqueous solutions, non-aqueous solutions, from melts. Electrolysis of Al.
Electrolytic deposition of metal coatings on substrates. Electrolytic coating
of varnish for car industry. Principles of corrosion and surface protection.
|
||
|
Title
|
Macromolecular Chemistry
|
||
|
Code
|
ÚCHV/MMU/03
|
Teacher
|
Kladeková Daniela, Markušová Kvetoslava
|
|
ECTS credits
|
4
|
Hrs/week
|
3/-
|
|
Assessment
|
Examination
|
Semester
|
1
|
|
T/L method
|
Lecture
|
||
|
Objective
|
To make
students familiar with available structures of polymers and their synthesis
methods as well as with the ways that structure is reflected in their properties.
|
||
|
Content
|
Fundamental
aspects of chemical composition of polymers-monomers; shape and the
relationship between structure and properties. Primary, secondary, tertiary
and quaternary structures. Thermal transition. Molecular mass distributions.
Determination of molecular mass of macromolecules. Synthetic methods of
functional polymers and their characterisation. Naturally occurring polymers:
their properties. Degradation of polymers. Polymers and the environment.
|
||
|
Recommended reading
|
Elias H.-G.: Macromolecules. Volume 1 (Structure and
Properties); Volume 2 (Synthesis, Materials, and Technology). Plenum Press,
New York, 1984
Moore W. J.: Physical Chemistry. Longman, London,1972
Munk P.: Introduction to Macromolecular Science. John
Wiley & Sons, New York, 1989
Atkins P. W.: Physical Chemistry. Oxford University
Press, Oxford, New York, 2002
|
||
|
Title
|
Kinetics and Catalysis
|
||
|
Code
|
ÚCHV/FKK1/03
|
Teacher
|
Oriňáková Renáta, Markušová Kvetoslava
|
|
ECTS credits
|
4
|
Hrs/week
|
2/1
|
|
Assessment
|
Examination
|
Semester
|
1
|
|
T/L method
|
Lecture, Practical
|
||
|
Objective
|
To develop
student understanding of the kinetics of different types of reactions, e.g.,
homogeneous and heterogeneous catalysis.
|
||
|
Content
|
Classification
of chemical reactions. Reaction rates. Rate laws. Reaction order. Elementary
reactions. Complicated reactions. Theory of chemical kinetics. Experimental
methods of chemical kinetics. Complex reactions mechanism. Explosions.
Photochemical reactions. Essence of adsorption, types of adsorption,
adsorption isotherms. Essence of catalytic processes. Catalysis influenced
phenomena. Homogeneous and heterogeneous catalysis. Enzymatic catalysis.
|
||
|
Alternate courses
|
ÚCHV/FKK1/99 orÚCHV/FKK1/02
|
||
|
Title
|
Quantum Chemistry
|
||
|
Code
|
ÚCHV/KOC1/01
|
Teacher
|
Danihel Ivan
|
|
ECTS credits
|
5
|
Hrs/week
|
3/1
|
|
Assessment
|
Examination
|
Semester
|
1
|
|
T/L method
|
Lecture, Practical
|
||
|
Objective
|
To have
students improve their knowledge in the field of valence-bond based on
molecular orbital theory (MO) and individually to perform basic quantum
chemical calculations (molecular geometry optimisation, transition states,
vibrational analysis, etc.).
|
||
|
Content
|
Development
of valence-bond theory. Time-independent Schrodinger equation. Basic
approximations in molecular orbital valence-bond theory. Variant methods of
calculation in the framework of molecular orbital valence-bond theory.
Chemical reactivity. Potential energy hypersurfaces of molecules. Reaction
coordinate. Calculation of absolute and relative equilibrium and rate
constants in gas phase. Solvatation energy calculation.
|
||
|
Alternate courses
|
ÚCHV/KOC1/99 orÚCHV/KOC1/00
|
||
|
Recommended reading
|
Jensen F.: Introduction to Computational Chemistry,
Wiley, 2000
Leach A.R.:
Molecular Modelling, Addison Wesley Longman Ltd. 1998
Náray-Szabó G., Surján P.R., Ángyán J.G.: Applied
Quantum
Chemistry, Akadémia Kiadó, Budapest, 1987
|
||
|
Title
|
Special Seminar
|
||
|
Code
|
ÚCHV/VSE1a/04
|
Teacher
|
Andruch Vasiľ, Reiffová Katarína, Gondová Taťána,
Vojteková Viera
|
|
ECTS credits
|
2
|
Hrs/week
|
-/2
|
|
Assessment
|
Assessment
|
Semester
|
1
|
|
T/L method
|
Practical
|
||
|
Content
|
Actual
problems of physical and analytical chemistry which are connected with the
solution of the students’ theses.
|
||
|
Title
|
Solid State Chemistry
|
||
|
Code
|
ÚCHV/CTF1/00
|
Teacher
|
Černák Juraj, Tkáčová Klára
|
|
ECTS credits
|
5
|
Hrs/week
|
2/1
|
|
Assessment
|
Examination
|
Semester
|
1
|
|
T/L method
|
Lecture, Practical
|
||
|
Objective
|
To provide
students with basic knowledge on the fundamentals and significance of solid
state chemistry and of reaction in the solid state.
|
||
|
Content
|
Historical
development of solid state chemistry and its significance for technological
progress. General fundamentals and important properties of solids: ideal and
real crystals, deformation of crystals, diffusion in solids. Non-catalysed
reactions involving solids: thermal decomposition, surface oxidation,
reaction between solids, chemical dissolution. The influence of
non-equilibrium defects on the reactivity of solids. Generation of defects by
various methods of treatment: rapid quenching, doping, irradiation,
mechanical activation and low temperature decomposition.
|
||
|
Alternate courses
|
ÚCHV/CTF1/99
|
||
|
Recommended reading
|
West A.R.: Basic Solid State Chemistry, J. Wiley,
Chichester, 1999
Tkáčová, K.: Mechanical Activation of Minerals.
Elsevier, Amsterdam, 1989.
|
||
|
Title
|
Atomic Spectrochemistry
|
||
|
Code
|
ÚCHV/AAS1/03
|
Teacher
|
Bazeľ Yaroslav, Vojteková Viera
|
|
ECTS credits
|
6
|
Hrs/week
|
2/2
|
|
Assessment
|
Examination
|
Semester
|
1
|
|
T/L method
|
Lecture, Practical
|
||
|
Objective
|
To provide
students with theoretical information and practical experience with atomic
absorption and emission methods used in analytical practice (environmental
analysis, material research, clinical and food analysis).
|
||
|
Content
|
Basic and enhanced
information about spectral (optical) methods; history of their development;
practical applications: optical analytical methods, principles,
classification; atomic spectra, creation, analytical use. Modern equipment
for scanning for radiation. Detection of radiation in spectrochemistry.
Historical development; actual trends. Photographical detection and its
particularities. Methodologies for
solution analysis; special methods for the direct transport of the solid
samples in the DCA source. Atomic absorption spectrometry, flame and
electrothermal atomisation. Methods based on the interaction of the RTG
radiation and the sample: advantages, disadvantages and applications of
WDXRF, EDXRF, TXRF.
|
||
|
Alternate courses
|
ÚCHV/AAS1/01
|
||
|
Recommended reading
|
D. A. Skoog, J. J. Leary: Instrumental Analytics. Springer,
Berlin - Heidelberg 1996
B. Welz, M. Sperling: Atomic Absorption Spectrometry,
Wiley-VCH Verlagsgesellschaft mbH, Germany 1998
2. Douglas A. Skoog, Donald M. West, F. James Holler,
Timothy A. Nieman: Principles of Instrumental Analysis, Wandsworth, 1997
|
||
|
Title
|
Analysis of Psychotropic and Narcotic Substances
|
||
|
Code
|
ÚCHV/APO1/02
|
Teacher
|
Gondová Taťána
|
|
ECTS credits
|
4
|
Hrs/week
|
2/-
|
|
Assessment
|
Examination
|
Semester
|
1
|
|
T/L method
|
Lecture
|
||
|
Content
|
Drugs; drug
dependence. Psychotropic and narcotic substances: classification, properties
and laws. Dose and tolerance, therapy, prevention. Pharmacokinetics of the
drug. Biological effects, biotransformations, receptors. The methods used in
the analysis of the drugs (clinical, forensic analysis): opiates, cocaine,
amphetamines and their analogues, hallucinogenics, cannabis products, etc.
|
||
|
Alternate courses
|
ÚCHV/APO1/99 orÚCHV/APO1/00
|
||
|
Title
|
Chromatographic Analysis
|
||
|
Code
|
ÚCHV/CHRA1/03
|
Teacher
|
Oriňák Andrej
|
|
ECTS credits
|
6
|
Hrs/week
|
2/2
|
|
Assessment
|
Examination
|
Semester
|
1
|
|
T/L method
|
Lecture, Practical
|
||
|
Content
|
General
characteristics of chromatographic system and chromatographic
separation. Analyte retention in
chromatography; retention indices. Models used for chromatographic system
description. Parameters affecting quality of chromatographic separation. Sensitivity, separated analytes, separation
time, optimisation of chromatographic process. General equation of
chromatography. Evaluation of retention and selectivity of chromatographic
process. Stationary phase. Qualitative chromatographic analysis. Quantitative
analysis methods; sample preparation. System of analyte separation.
Identification in chromatographic analysis.
|
||
|
Title
|
Practical in Physical Chemistry
|
||
|
Code
|
ÚCHV/PFCU/03
|
Teacher
|
Markušová Kvetoslava
|
|
ECTS credits
|
4
|
Hrs/week
|
-/3
|
|
Assessment
|
Assessment
|
Semester
|
1
|
|
T/L method
|
Practical
|
||
|
Objective
|
To allow
students to verify theoretical principles and to learn to describe each
technique involved in appropriate physical chemistry experiments.
|
||
|
Content
|
Experimental
verification of theoretical knowledge involving thermodynamics,
thermochemistry, chemical equilibria (determination of enthalpy, phase
diagrams), colligative properties (cryoscopy, ebulioscopy), adsorption.
Experimental verification of theoretical knowledge involving electrochemistry
(conductivity, dissociation constants, potentials, electromotoric potentials
of cells, activity coefficients, polarography) and chemical kinetics (determination
of rate constants).
|
||
|
Recommended reading
|
Levitt B. P.: Findlay´s Practical Physical Chemistry.
Longman, London, 1973
Moore W. J.: Physical Chemistry. Longman, London,
1972
Atkins P. W.: Physical Chemistry. Oxford University
Press, Oxford, New York, 2002
|
||
|
Title
|
Bioanalytical Chemistry
|
||
|
Code
|
ÚCHV/BACH1/03
|
Teacher
|
Reiffová Katarína, Bazeľ Yaroslav
|
|
ECTS credits
|
5
|
Hrs/week
|
2/1
|
|
Assessment
|
Examination
|
Semester
|
1, 3
|
|
T/L method
|
Lecture, Practical
|
||
|
Objective
|
To impart
theoretical knowledge and to give practical experience to students about the
application of analytical chemistry and analytical methods to clinical
chemistry, clinical biochemistry, haematology, microbiology and immunology.
|
||
|
Content
|
Introduction
to bioanalytical chemistry. Biological sample; classification. Sampling
techniques, transport, sample storing and conservation. Selected methods of
sample pre-treatment for bio- analysis. Conditions for analytical method
selection. Presentation of analytical data evaluation. Optimisation of analytical
procedure. Control and management of quality in clinical laboratory.
Molecules colouring and their analytical applications. Enzymes in
bioanalysis. Immunochemical methods.
Microbiological methods.
Analysis
of
biomolecules separation methods selection. Analytical technique of
miniaturisation: principle, microchips, biosensors.
|
||
|
Recommended reading
|
Mikkelsen S.R, Cortón E.: Bioanalytical Chemistry,
Wiley, 2004
Wilson I.: Bioanalytical Separations 4, (Handbook of
Analytical Separations), Elsevier, 2003
|
||
|
Title
|
Electroanalytical Methods
|
||
|
Code
|
ÚCHV/FEM/03
|
Teacher
|
Markušová Kvetoslava
|
|
ECTS credits
|
6
|
Hrs/week
|
2/2
|
|
Assessment
|
Examination
|
Semester
|
1, 3
|
|
T/L method
|
Lecture, Practical
|
||
|
Objective
|
To provide
students a survey of the principles, theoretical background and practical
applications of modern electroanalytical methods.
|
||
|
Content
|
Importance
of electroanalytical methods for environmental control and protection,
requirements of practice, electrochemical cells, electrode potential, mass
transfer by convection, migration and diffusion, Cottrell equation, direct
current voltametry and polarography (principle, theoretical backround,
examples of practical application). TAST polarography and voltametry,
staircase voltammetry, pulse techniques: normal pulse and differential pulse
voltammetry and polarography, square-wave voltammetry and polarography, AC
polarography and voltammetry, anodic stripping voltammetry, adsorptive (or
accumulation) voltammetry (applications in clinical and environmental
analysis), working electrodes in voltammetry: stationary mercury electrode,
mercury film electrode, glassy carbon electrode, carbon paste electrode,
metallic electrodes, rotating disk electrode, rotating ring-disk electrode,
ultramicroelectrodes, chemically modified electrodes, potentiometry,
principles of ion selective electrodes, glass electrodes, ISE with solid and
liquid membranes, biocatalytic membrane electrodes, chronopotentiometry,
potentiometric stripping analysis, electroanalytic-al detectors in flow
systems, amperometric titrations, biamperometric and bipotentiometric
titrations, potentiostatic and galvanostatic coulometry.
|
||
|
Recommended reading
|
F. Scholtz: Electroanalytical Methods, Springer
Verlsag, Heidelberg 2002, ISBN 3-540-42449-3
J. Wang: Analytical Electrochemistry, VCH Publ., New
York 1994, 2000
R. Kalvoda
(Ed.): Electroanalytical Methods in Chemical and Environmental Analysis,
Plenum Publ. Corp., New York 1987.
A. J. Bard, L. R. Faulkner: Electrochemical Methods,
John Wiley and Sons, New York 1980
T. Riley, A. Watson: Polarography and Other
Voltametric Methods, John Wiley and Sons, Chichester 1987
J. Wang: Stripping Analysis, VCH Publ. Inc.,
Deerfield Beach 1985
|
||
Tidak ada komentar:
Posting Komentar